abstract：:New thio- and seleno-analogs of psoralen were synthesized and analyzed for their photoreactivity toward DNA. Using oligonucleotides of defined sequence, we first showed that these derivatives predominantly generated interstrand crosslinks at 5'-TpA sites. We also observed a surprisingly high reactivity of 7H-thiopyran...

journal_title：Photochemistry and photobiology

authors： Collet M,Sage E,Piette J

更新日期：1997-08-01 00:00:00

abstract：:In photodynamic therapy with topically applied delta-aminolevulinic acid porphyrins are acting as photosensitizers. The profile of porphyrin metabolites in normal or in neoplastic skin after administration of delta-aminolevulinic acid has not been determined in detail yet. Thus, to study porphyrin biosynthesis in huma...

journal_title：Photochemistry and photobiology

authors： Fritsch C,Batz J,Bolsen K,Schulte KW,Zumdick M,Ruzicka T,Goerz G

更新日期：1997-07-01 00:00:00

abstract：:The potential for electron transfer quenching of rose bengal triplet (3RB2-) to compete with energy transfer quenching by oxygen was evaluated. Rate constants for oxidative and reductive quenching were measured in buffered aqueous solution, acetonitrile and in small unilamellar liposomes using laser flash photolysis. ...

journal_title：Photochemistry and photobiology

authors： Lambert CR,Kochevar IE

更新日期：1997-07-01 00:00:00

abstract：:Pyrimidine dimers were measured in epidermal DNA of SKH:HR1 mice following exposure to solar-simulated UV radiation (SSUV, 290-400 nm) or to UVA (320-400 nm). Mice were exposed to SSUV or UVA after topical application (2 mg/cm2) of vehicle, a UVB absorber (5% 2-ethylhexyl p-methoxycinnamate [2-EHMC]), or a broad-spect...

journal_title：Photochemistry and photobiology

authors： Ley RD,Fourtanier A

更新日期：1997-06-01 00:00:00

abstract：:We have investigated the factors that affect the virucidal activity of methylene blue (MB) photosensitization. The M13 bacteriophage was more rapidly inactivated at higher temperatures (6 degrees C < 24 degrees C < 38 degrees C). Rate constants for inactivation were 0.072, 0.139 and 0.260 (log10 inactivation)/ (J/cm2)...

journal_title：Photochemistry and photobiology

authors： Abe H,Wagner SJ,Kuwabara M,Kamo N,Ikebuchi K,Sekiguchi S

更新日期：1997-05-01 00:00:00

abstract：:The effect of charge on the cellular uptake, localization and phototoxicity of conjugates between chlorin(e6) (ce6) and poly-L-lysine was studied in vitro. These conjugates (average MW 35-55 kDa) were synthesized to have polycationic, polyanionic or neutral charges. Two human cell lines (A431 epidermoid carcinoma cell...

journal_title：Photochemistry and photobiology

authors： Soukos NS,Hamblin MR,Hasan T

更新日期：1997-04-01 00:00:00

abstract：:The efficiency of ruthenium complexes for photosensitizing DNA damage depends on the oxidizing character of their ligands. Here we report on the difference in behavior of tris(2.2'-bipyrazyl)ruthenium(II) (Ru[bpz]3(2+)), tris(2,2'-bipyridyl)ruthenium(II) (Ru[bipy]3(2+)) and cis-dichlorobis (2,2'-bipyrazyl)ruthenium(II...

journal_title：Photochemistry and photobiology

authors： Vicendo P,Mouysset S,Paillous N

更新日期：1997-04-01 00:00:00

abstract：:Because metallothionein (MT) is elevated and may be protective in UV-irradiated skin, we have studied the effects of UV and other agents on MT transcription using the sheep MT 1A promoter, linked to the beta-galactosidase gene and stably transfected into human cell lines. beta-galactosidase reporter activity was induc...

journal_title：Photochemistry and photobiology

authors： Hansen C,Ablett E,Green A,Sturm RA,Dunn IS,Fairlie DP,West ML,Parsons PG

更新日期：1997-03-01 00:00:00

abstract：:Previous studies with methylene blue (MB) in red cell suspensions have demonstrated that extracellular, but not intracellular, virus can be readily photoinactivated. To test if the resistance of intracellular virus to inactivation is related to the permanent positive charge of the phenothiazine, a series of uncharged ...

journal_title：Photochemistry and photobiology

authors： Skripchenko A,Robinette D,Wagner SJ

更新日期：1997-03-01 00:00:00

abstract：:In this study our aim was to determine the biophysical values of constitutive skin color in Caucasians and to define the correlation between skin color and phototype assessed according to the Fitzpatrick method. Constitutive skin color was measured on the buttock, with a Minolta CR-200 colorimeter, in a population-of ...

journal_title：Photochemistry and photobiology

authors： Rubegni P,Cevenini G,Flori ML,Fimiani M,Stanghellini E,Molinu A,Barbini P,Andreassi L

更新日期：1997-02-01 00:00:00

abstract：:A visual chromophore analogue, 10-methyl-13-demethyl (dm) retinal, was synthesized and reconstituted with bleached bovine rhodopsin to form a visual pigment derivative with absorbance maximum at 505 nm. The investigations with this new compound were stimulated from recent results using 13-dm retinal as a chromophore t...

journal_title：Photochemistry and photobiology

authors： Koch D,Gärtner W

更新日期：1997-01-01 00:00:00

abstract：:When Escherichia coli cells were irradiated by UVA in the presence of 6-mercaptopurine (6-MP) or 2-thiouracil (S2Ura), two kinds of repair-deficient strains of recA- and uvrA- were killed more efficiently than the parental wild-type strain having normal repair capacities. In addition, these agents with UVA exposure gr...

journal_title：Photochemistry and photobiology

authors： Komeda K,Iwamoto S,Kominami S,Ohnishi T

更新日期：1997-01-01 00:00:00

abstract：:It has previously been demonstrated that chronic low-dose solar-simulated UV radiation could induce both local and systemic immunosuppression as well as tolerance to a topically applied hapten. In this study, we have used a chronic low-dose UV-irradiation protocol to investigate the effects of UVA on the skin immune s...

journal_title：Photochemistry and photobiology

authors： Bestak R,Halliday GM

更新日期：1996-12-01 00:00:00

abstract：:Iranian firefly larvae, Lampyris turkestanicus collected from north of Iran and their luciferin were analyzed by HPLC, TLC, MS and spectroscopic Fourier transform ([FT]-IR, FT-NMR, UV and fluorescence) methods. The results showed that luciferin in L turkestanicus lanterns was the same as in the American firefly, Photi...

journal_title：Photochemistry and photobiology

authors： Hadj-Mohammadi MR,Chaichi MJ

更新日期：1996-11-01 00:00:00

abstract：:A portable fluorimeter was developed and utilized to acquire fluorescence spectra from 381 cervical sites in 95 patients at 337, 380 and 460 nm excitation immediately prior to colposcopy. A multivariate statistical algorithm was used to extract clinically useful information from tissue spectra acquired in vivo. Two fu...

journal_title：Photochemistry and photobiology

authors： Ramanujam N,Mitchell MF,Mahadevan-Jansen A,Thomsen SL,Staerkel G,Malpica A,Wright T,Atkinson N,Richards-Kortum R

更新日期：1996-10-01 00:00:00

abstract：:Evanescent wave illumination with total internal reflection is often used to provide excitation near a quartz-water interface. We now show that evanescent illumination at one wavelength and incident angle, coupled with light quenching at a second wavelength and incident angle, can be used for selective excitation of f...

journal_title：Photochemistry and photobiology

authors： Lakowicz JR,Gryczynski Z,Gryczynski I

更新日期：1996-10-01 00:00:00

abstract：:Light emitted by electronic photographic flash units is shown to damage bacteria and human skin fibroblasts deficient in repair systems, with survival curves very similar to those produced by 254 nm short UV. The lesions induced by these flashes are as photorepairable by the photolyase enzyme as those induced by 254 n...

journal_title：Photochemistry and photobiology

authors： Menezes S,Monteiro C

更新日期：1996-09-01 00:00:00

abstract：:Magnetic field effect studies of alkylcobalamin photolysis provide evidence for the formation of a reactive radical pair that is born in the singlet spin state. The radical pair recombination process that is responsible for the magnetic field dependence of the continuous-wave (CW) quantum yield is limited to the diffu...

journal_title：Photochemistry and photobiology

authors： Natarajan E,Grissom CB

更新日期：1996-08-01 00:00:00

abstract：:Patients infected with human immunodeficiency virus (HIV) have a high prevalence of UV radiation-responsive skin diseases including psoriasis, pruritus, eosinophilic folliculitis and eczemas. On the other hand, UV has been shown to suppress T cell-mediated immune responses and to induce activation and replication of H...

journal_title：Photochemistry and photobiology

authors： Adams ML,Houpt KR,Cruz PD Jr

更新日期：1996-08-01 00:00:00

abstract：:The psaI and psaL genes were characterized from the cyanobacterium Synechococcus sp. strain PCC 7002. The gene organization was different from that reported for other cyanobacteria with psaI occurring upstream and being divergently transcribed from the psaL gene. Mutants lacking PsaI or PsaL were generated by interpos...

journal_title：Photochemistry and photobiology

authors： Schluchter WM,Shen G,Zhao J,Bryant DA

更新日期：1996-07-01 00:00:00

abstract：:Hypericin is a naturally occurring photosensitizer, whose presence in plants has been responsible for cutaneous phototoxicity in grazing animals. The photosensitizing properties of this agent have recently been exploited in models for anti-tumor and anti-viral activity. The cytotoxicity of hypericin and light was asse...

journal_title：Photochemistry and photobiology

authors： Yu H,Wolford ST,Kegode R,Zhao W,Osweller GD

更新日期：1996-07-01 00:00:00

abstract：:Lutetium texaphyrin, PCI-0123, is a pure, water-soluble photosensitizer with a large broad absorption band centered at 732 nm. The compound was tested for photodynamic therapy (PDT) effectiveness in a murine mammary cancer model. The texaphyrin macrocycle as illustrated by magnetic resonance imaging and 14C-radiolabel...

journal_title：Photochemistry and photobiology

authors： Young SW,Woodburn KW,Wright M,Mody TD,Fan Q,Sessler JL,Dow WC,Miller RA

更新日期：1996-06-01 00:00:00

abstract：:We describe here the development of monoclonal antibodies to the hapten tryptophan-riboflavin, generated by irradiation of a solution of bovine serum albumin in the presence of riboflavin. The specificity of the three obtained monoclonal antibodies, named 1E6, 5H5, 5A8 all belonging to the IgG1 isotype, was assessed b...

journal_title：Photochemistry and photobiology

authors： Diaz M,Becker MI,De Ioannes AE,Silva E

更新日期：1996-06-01 00:00:00

abstract：:The retina and retinal pigment epithelium contain a number of retinoids in a metabolic pathway that eventually forms the visual pigments. This study investigates the photochemistry of those retinoids that may contribute to light-induced damage to the retina. These include retinal (RAL), retinol (ROL), retinylpalmitate...

journal_title：Photochemistry and photobiology

authors： Dillon J,Gaillard ER,Bilski P,Chignell CF,Reszka KJ

更新日期：1996-05-01 00:00:00

abstract：:The aim of this investigation is the evaluation of DNA interaction of with tetraruthenated porphyrin (TRP) and of DNA damage in the presence of light. Direct-fluorescence and electronic absorption measurements after incubation of DNA with TRP indicate strong binding between pBR322 DNA or calf thymus DNA with the modif...

journal_title：Photochemistry and photobiology

authors： Onuki J,Ribas AV,Medeiros MH,Araki K,Toma HE,Catalani LH,Di Mascio P

更新日期：1996-03-01 00:00:00

abstract：:The synthesis of some bromine-substituted rhodamine derivatives viz., 4,5-dibromorhodamine methyl ester (dye 2) and 4,5-dibromorhodamine n-butyl ester (dye 3) are reported. These dyes were synthesized to promote a more efficient cancer cell photosensitizer for potential use in in vitro bone marrow purging in preparati...

journal_title：Photochemistry and photobiology

authors： Pal P,Zeng H,Durocher G,Girard D,Li T,Gupta AK,Giasson R,Blanchard L,Gaboury L,Balassy A,Turmel C,Laperrière A,Villeneuve L

更新日期：1996-02-01 00:00:00

abstract：:Work in the past 8 years, particularly in the past 1-2 years, has greatly expanded our understanding of the mechanisms by which ultraviolet irradiation stimulates melanogenesis in the skin. A direct effect of UV photons on DNA results in up-regulation of the gene for tyrosinase, the rate-limiting enzyme in melanin syn...

journal_title：Photochemistry and photobiology

authors： Gilchrest BA,Park HY,Eller MS,Yaar M

更新日期：1996-01-01 00:00:00

abstract：:The photodynamic therapy (PDT) activity of the bis(dimethylthexylsiloxy)silicon 2,3-naphthalocyanine (SiNc 8) was evaluated against the EMT-6 tumor implanted intradermally in BALB/c mice. The SiNc 8 was formulated in aqueous emulsions based on Cremophor EL or Solutol HS 15. The formulation was shown to affect plasma c...

journal_title：Photochemistry and photobiology

authors： Brasseur N,Ouellet R,Lewis K,Potter WR,van Lier JE

更新日期：1995-12-01 00:00:00

abstract：:Microscopic fluorescence photometry incorporating a light-sensitive thermo-electrically cooled charge-coupled device (CCD) camera was employed to investigate the fluorescence distribution of 5-aminolevulinic acid (ALA)-induced porphyrins in 22 patients with a total number of 52 noduloulcerative basal cell carcinomas (...

journal_title：Photochemistry and photobiology

authors： Peng Q,Warloe T,Moan J,Heyerdahl H,Steen HB,Nesland JM,Giercksky KE

更新日期：1995-11-01 00:00:00

abstract：:Cellular autofluorescence spectra were monitored in a single-beam gradient force optical trap ("optical tweezers") in order to probe the physiological effects of near infrared and UVA (320-400 nm) microirradiation. Prior to trapping, Chinese hamster ovary cells exhibited weak UVA-excited autofluorescence with maxima a...

journal_title：Photochemistry and photobiology

authors： König K,Liu Y,Sonek GJ,Berns MW,Tromberg BJ

更新日期：1995-11-01 00:00:00

abstract：:Alignment of the primary structures of the hydrozoan photoproteins, aequorin, mitrocomin, clytin and obelin showed very strong amino acid sequence identities. The Ca(2+)-binding sites of the proteins were found to be highly conserved. The Ca(2+)-binding sites were also homologous to the Ca(2+)-binding sites of other C...

journal_title：Photochemistry and photobiology

authors： Tsuji FI,Ohmiya Y,Fagan TF,Toh H,Inouye S

更新日期：1995-10-01 00:00:00

abstract：:Confocal laser microspectrofluorometric measurements on human T47D mammary tumor cells have been performed to assess the intracellular distribution of hypericin within the various cell compartments: cytoplasmic membrane, cytoplasm and nucleus. Confocal fluorescence measurements obtained from microvolumes (approximatel...

journal_title：Photochemistry and photobiology

authors： Miskovsky P,Sureau F,Chinsky L,Turpin PY

更新日期：1995-09-01 00:00:00

abstract：:Quantum yields for the formation of superoxide ions, O2-., and singlet oxygen, 1O2, were determined during the photolyses of gilvocarcin M (GM) in air-saturated dry dimethylsulfoxide (DMSO) and in 45:55 (vol/vol) DMSO-water mixtures. The quantum yield for the photoreduction of methyl viologen by GM in nitrogen-saturat...

journal_title：Photochemistry and photobiology

authors： Alegría AE,Zayas L,Guevara N

更新日期：1995-09-01 00:00:00

abstract：:Use of near infrared instead of visible light would markedly improve tissue penetration, making larger tumors candidates for photochemotherapy. Because common photesensitizers exhibit virtually no absorption in this wavelength region, conditions are required where the simultaneous action of two photons is possible. He...

journal_title：Photochemistry and photobiology

authors： Lenz P

更新日期：1995-08-01 00:00:00

abstract：:Cis-urocanic acid (UCA), formed in the epidermis by UV irradiation of trans-UCA, has been implicated as a mediator of the immunosuppression induced by UV exposure of the skin. This review covers recent work in which the wavelength dependence of cis-UCA formation, the interaction of UCA isomers with DNA, the effects of...

journal_title：Photochemistry and photobiology

authors： Norval M,Gibbs NK,Gilmour J

更新日期：1995-08-01 00:00:00

abstract：:The interaction between human alpha1-acid glycoprotein (orosomucoid) and the fluorescent probe, 2-p-toluidinylnaphthalene-6-sulfonate (TNS) has been studied. An association constant of 16.7 (+/- 3) x 10(3) M-1 was obtained for the complex at 20 degrees C with a stoichiometry of 1:1. From the effect of temperature on t...

journal_title：Photochemistry and photobiology

authors： Albani J,Vos R,Willaert K,Engelborghs Y

更新日期：1995-07-01 00:00:00

abstract：:Ultraviolet-A irradiation of a suprofen (2-[4-2(2-thenoyl) phenyl]propionic acid) (SPF) buffered solution (pH 7.4) in the presence of supercoiled pBR322 DNA leads to single strand breaks with the formation of an open circular form and subsequent linearization of the plasmid. On the basis of agarose gel electrophoresis...

journal_title：Photochemistry and photobiology

authors： Condorelli G,Constanzo LL,De Guidi G,Giuffrida S,Sortino S

更新日期：1995-07-01 00:00:00

abstract：:To improve the understanding of human skin autofluorescence emission, the spectroscopic and microscopic characteristics of skin autofluorescence were studied using a combined fluorescence and reflectance spectroanalyzer and a fiber optic microspectrophotometer. The autofluorescence spectra of in vivo human skin were m...

journal_title：Photochemistry and photobiology

authors： Zeng H,MacAulay C,McLean DI,Palcic B

更新日期：1995-06-01 00:00:00

abstract：:Antibodies and antigen binding fragments thereof were photochemically immobilized on surface-modified silicon chips of 5 x 5 mm size. Silicon surface-grafted diazirines and benzophenones formed covalent bonds with the immunoreagents on light activation. Photolithographic immobilization of monoclonal antibodies in aque...

journal_title：Photochemistry and photobiology

authors： Sundarababu G,Gao H,Sigrist H

更新日期：1995-06-01 00:00:00

abstract：:A diffusible multitherapy resistance factor (MTRF) is produced by Cloudman S91 melanoma cells in vitro. The MTRF decreases sensitivity of the target cell line, S91/amel, to gamma-irradiation, UVC (200-280 nm) and mitomycin C (MMC). In the present study, we demonstrate that MTRF also increases the survival of S91/amel ...

journal_title：Photochemistry and photobiology

authors： Hill HZ,Hill GJ,Cieszka K,Azure M,Chowdhary I,Sayre RM

更新日期：1995-05-01 00:00:00